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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vestar</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник аритмологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Arrhythmology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-8641</issn><issn pub-type="epub">2658-7327</issn><publisher><publisher-name>НАО «Инкарт»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25760/VA-2018-93-64-72.</article-id><article-id custom-type="elpub" pub-id-type="custom">vestar-122</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИКУЮЩИМ ВРАЧАМ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GUIDE TO PRACTITIONERS</subject></subj-group></article-categories><title-group><article-title>АНТИТРОМБОТИЧЕСКАЯ ТЕРАПИЯ У БОЛЬНЫХ С ФИБРИЛЛЯЦИЕЙ ПРЕДСЕРДИЙ ПОСЛЕ ЧРЕСКОЖНОГО КОРОНАРНОГО ВМЕШАТЕЛЬСТВА: ПРИШЛО ВРЕМЯ ОГРАНИЧИТЬСЯ ДВУМЯ ПРЕПАРАТАМИ?</article-title><trans-title-group xml:lang="en"><trans-title>ANTITHROMBOTIC THERAPY IN PATIENTS WITH ATRIAL FIBRILLATION FOLLOWING PERCUTANEOUS CORONARY INTERVENTION: IS IT TIME TO BE CONFINED TO DUAL THERAPY?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Канорский</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kanorsky</surname><given-names>S. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБОУ ВО Кубанский государственный медицинский университет МЗ РФ</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>17</day><month>04</month><year>2019</year></pub-date><volume>0</volume><issue>93</issue><fpage>64</fpage><lpage>72</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Канорский С.Г., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Канорский С.Г.</copyright-holder><copyright-holder xml:lang="en">Kanorsky S.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestar.elpub.ru/jour/article/view/122">https://vestar.elpub.ru/jour/article/view/122</self-uri><abstract><p>Представлены основные положения действующих рекомендаций по ведению больных с фибрилляцией предсердий, нуждающихся в антикоагулянтной терапии, после перенесенного чрескожного коронарного вмешательства; обсуждается возможность оптимизации тактики лечения данной категории пациентов с учетом результатов недавних рандомизированных исследований.</p></abstract><trans-abstract xml:lang="en"><p>Key elements of current guidelines on management of patients with atrial fibrillation and indications to anticoagulant therapy after percutaneous coronary intervention are given; a potential of optimization of treatment strategy of these patients is discussed taking the results of recent randomized studies into account.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фибрилляция предсердий</kwd><kwd>чрескожное коронарное вмешательство</kwd><kwd>острые коронарные синдромы</kwd><kwd>прямые оральные антикоагулянты</kwd><kwd>антитромбоцитарные препараты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>atrial fibrillation</kwd><kwd>percutaneous coronary intervention</kwd><kwd>acute coronary syndromes</kwd><kwd>direct oral anticoagulants</kwd><kwd>antiplatelet medications</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kirchhof P., Benussi S., Kotecha D. et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J. 2016; 37(38): 2893-2962. doi: 10.1093/eurheartj/ehw210.</mixed-citation><mixed-citation xml:lang="en">Kirchhof P., Benussi S., Kotecha D. et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J. 2016; 37(38): 2893-2962. doi: 10.1093/eurheartj/ehw210.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Schömig A., Neumann F.J., Kastrati A. et al. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Engl J Med. 1996; 334(17): 1084-1089. doi: 10.1056/NEJM199604253341702.</mixed-citation><mixed-citation xml:lang="en">Schömig A., Neumann F.J., Kastrati A. et al. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Engl J Med. 1996; 334(17): 1084-1089. doi: 10.1056/NEJM199604253341702.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Leon M.B., Baim D.S., Popma J.J. et al. A clinical trial comparing three antithrombotic-drug regimens after coronaryartery stenting. Stent Anticoagulation Restenosis Study Investigators. N Engl J Med. 1998; 339(23): 1665-1671. doi: 10.1056/NEJM199812033392303.</mixed-citation><mixed-citation xml:lang="en">Leon M.B., Baim D.S., Popma J.J. et al. A clinical trial comparing three antithrombotic-drug regimens after coronaryartery stenting. Stent Anticoagulation Restenosis Study Investigators. N Engl J Med. 1998; 339(23): 1665-1671. doi: 10.1056/NEJM199812033392303.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kerneis M., Talib U., Nafee T. et al. Triple Antithrombotic Therapy for Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention. Prog Cardiovasc Dis. 2018; 60(4-5): 524-530. doi: 10.1016/j.pcad.2018.01.008.</mixed-citation><mixed-citation xml:lang="en">Kerneis M., Talib U., Nafee T. et al. Triple Antithrombotic Therapy for Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention. Prog Cardiovasc Dis. 2018; 60(4-5): 524-530. doi: 10.1016/j.pcad.2018.01.008.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">January C.T., Wann L.S., Alpert J.S. et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2014; 64(21): e1-e76. doi: 10.1016/j.jacc.2014.03.022.</mixed-citation><mixed-citation xml:lang="en">January C.T., Wann L.S., Alpert J.S. et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2014; 64(21): e1-e76. doi: 10.1016/j.jacc.2014.03.022.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Angiolillo D.J., Goodman S.G., Bhatt D.L. et al. Antithrombotic Therapy in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A North American Perspective-2016 Update. Circ Cardiovasc Interv. 2016; 9(11). doi: 10.1161/circinterventions.116.004395.</mixed-citation><mixed-citation xml:lang="en">Angiolillo D.J., Goodman S.G., Bhatt D.L. et al. Antithrombotic Therapy in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A North American Perspective-2016 Update. Circ Cardiovasc Interv. 2016; 9(11). doi: 10.1161/circinterventions.116.004395.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lip G.Y., Windecker S., Huber K. et al. Management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous coronary or valve interventions: a joint consensus document of the European Society of Cardiology Working Group on Thrombosis, European Heart Rhythm Association (EHRA), European Association of Percutaneous Cardiovascular Interventions (EAPCI) and European Association of Acute Cardiac Care (ACCA) endorsed by the Heart Rhythm Society (HRS) and Asia-Pacific Heart Rhythm Society (APHRS). Eur Heart J. 2014; 35(45): 3155-3179. doi: 10.1093/eurheartj/ehu298.</mixed-citation><mixed-citation xml:lang="en">Lip G.Y., Windecker S., Huber K. et al. Management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous coronary or valve interventions: a joint consensus document of the European Society of Cardiology Working Group on Thrombosis, European Heart Rhythm Association (EHRA), European Association of Percutaneous Cardiovascular Interventions (EAPCI) and European Association of Acute Cardiac Care (ACCA) endorsed by the Heart Rhythm Society (HRS) and Asia-Pacific Heart Rhythm Society (APHRS). Eur Heart J. 2014; 35(45): 3155-3179. doi: 10.1093/eurheartj/ehu298.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Capodanno D., Angiolillo D.J. Management of antiplatelet and anticoagulant therapy in patients with atrial fibrillation in the setting of acute coronary syndromes or percutaneous coronary interventions. Circ Cardiovasc Interv. 2014; 7(1): 113-124. doi: 10.1161/circinterventions.113.001150.</mixed-citation><mixed-citation xml:lang="en">Capodanno D., Angiolillo D.J. Management of antiplatelet and anticoagulant therapy in patients with atrial fibrillation in the setting of acute coronary syndromes or percutaneous coronary interventions. Circ Cardiovasc Interv. 2014; 7(1): 113-124. doi: 10.1161/circinterventions.113.001150.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hansen M.L., Sørensen R., Clausen M.T. et al. Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation. Arch Intern Med. 2010; 170(16): 1433-1441. doi: 10.1001/archinternmed.2010.271.</mixed-citation><mixed-citation xml:lang="en">Hansen M.L., Sørensen R., Clausen M.T. et al. Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation. Arch Intern Med. 2010; 170(16): 1433-1441. doi: 10.1001/archinternmed.2010.271.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Mega J., Carreras E.T. Antithrombotic therapy: triple therapy or triple threat? Hematology Am Soc Hematol Educ Program. 2012; 2012: 547-552. doi: 10.1182/asheducation-2012.1.547.</mixed-citation><mixed-citation xml:lang="en">Mega J., Carreras E.T. Antithrombotic therapy: triple therapy or triple threat? Hematology Am Soc Hematol Educ Program. 2012; 2012: 547-552. doi: 10.1182/asheducation-2012.1.547.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Dans A.L., Connolly S.J., Wallentin L. et al. Concomitant use of antiplatelet therapy with dabigatran or warfarin in the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial. Circulation. 2013; 127(5): 634-640. doi: 10.1161/circulationaha.112.115386.</mixed-citation><mixed-citation xml:lang="en">Dans A.L., Connolly S.J., Wallentin L. et al. Concomitant use of antiplatelet therapy with dabigatran or warfarin in the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial. Circulation. 2013; 127(5): 634-640. doi: 10.1161/circulationaha.112.115386.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Dewilde W.J., Oirbans T., Verheugt F.W. et al. Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial. Lancet. 2013; 381(9872): 1107-1115. doi: 10.1016/S0140-6736(12)62177-1.</mixed-citation><mixed-citation xml:lang="en">Dewilde W.J., Oirbans T., Verheugt F.W. et al. Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial. Lancet. 2013; 381(9872): 1107-1115. doi: 10.1016/S0140-6736(12)62177-1.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Fiedler K.A., Maeng M., Mehilli J. et al. Duration of Triple Therapy in Patients Requiring Oral Anticoagulation After Drug-Eluting Stent Implantation: The ISAR-TRIPLE Trial. J Am Coll Cardiol. 2015; 65(16): 1619-1629. doi: 10.1016/j.jacc.2015.02.050.</mixed-citation><mixed-citation xml:lang="en">Fiedler K.A., Maeng M., Mehilli J. et al. Duration of Triple Therapy in Patients Requiring Oral Anticoagulation After Drug-Eluting Stent Implantation: The ISAR-TRIPLE Trial. J Am Coll Cardiol. 2015; 65(16): 1619-1629. doi: 10.1016/j.jacc.2015.02.050.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Gibson C.M., Mehran R., Bode C. et al. Prevention of Bleeding in Patients with Atrial Fibrillation Undergoing PCI. N Engl J Med. 2016; 375(25): 2423-2434. doi: 10.1056/NEJMoa1611594.</mixed-citation><mixed-citation xml:lang="en">Gibson C.M., Mehran R., Bode C. et al. Prevention of Bleeding in Patients with Atrial Fibrillation Undergoing PCI. N Engl J Med. 2016; 375(25): 2423-2434. doi: 10.1056/NEJMoa1611594.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cannon C.P., Bhatt D.L., Oldgren J. et al. Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation. N Engl J Med. 2017; 377(16): 1513-1524. doi: 10.1056/NEJMoa1708454.</mixed-citation><mixed-citation xml:lang="en">Cannon C.P., Bhatt D.L., Oldgren J. et al. Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation. N Engl J Med. 2017; 377(16): 1513-1524. doi: 10.1056/NEJMoa1708454.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Roffi M., Patrono C., Collet J.P. et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016; 37(3): 267-315. doi: 10.1093/eurheartj/ehv320.</mixed-citation><mixed-citation xml:lang="en">Roffi M., Patrono C., Collet J.P. et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016; 37(3): 267-315. doi: 10.1093/eurheartj/ehv320.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Bavishi C., Panwar S., Messerli F.H., Bangalore S. Meta-Analysis of Comparison of the Newer Oral P2Y12 Inhibitors (Prasugrel or Ticagrelor) to Clopidogrel in Patients With Non-ST-Elevation Acute Coronary Syndrome. Am J Cardiol. 2015; 116(5): 809-817. doi: 10.1016/j.amjcard.2015.05.058.</mixed-citation><mixed-citation xml:lang="en">Bavishi C., Panwar S., Messerli F.H., Bangalore S. Meta-Analysis of Comparison of the Newer Oral P2Y12 Inhibitors (Prasugrel or Ticagrelor) to Clopidogrel in Patients With Non-ST-Elevation Acute Coronary Syndrome. Am J Cardiol. 2015; 116(5): 809-817. doi: 10.1016/j.amjcard.2015.05.058.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Valgimigli M., Bueno H., Byrne R.A. et al. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: The Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2018; 39(3): 213-260. doi: 10.1093/eurheartj/ehx419.</mixed-citation><mixed-citation xml:lang="en">Valgimigli M., Bueno H., Byrne R.A. et al. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: The Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2018; 39(3): 213-260. doi: 10.1093/eurheartj/ehx419.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Sarafoff N., Martischnig A., Wealer J et al. Triple therapy with aspirin, prasugrel, and vitamin K antagonists in patients with drug-eluting stent implantation and an indication for oral anticoagulation. J Am Coll Cardiol. 2013; 61(20): 2060-2066. doi: 10.1016/j.jacc.2013.02.036.</mixed-citation><mixed-citation xml:lang="en">Sarafoff N., Martischnig A., Wealer J et al. Triple therapy with aspirin, prasugrel, and vitamin K antagonists in patients with drug-eluting stent implantation and an indication for oral anticoagulation. J Am Coll Cardiol. 2013; 61(20): 2060-2066. doi: 10.1016/j.jacc.2013.02.036.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kereiakes D.J., Yeh R.W., Massaro J.M. et al. Antiplatelet therapy duration following bare metal or drug-eluting coronary stents: the dual antiplatelet therapy randomized clinical trial. JAMA. 2015; 313(11): 1113-1121. doi: 10.1001/jama.2015.1671.</mixed-citation><mixed-citation xml:lang="en">Kereiakes D.J., Yeh R.W., Massaro J.M. et al. Antiplatelet therapy duration following bare metal or drug-eluting coronary stents: the dual antiplatelet therapy randomized clinical trial. JAMA. 2015; 313(11): 1113-1121. doi: 10.1001/jama.2015.1671.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Valgimigli M., Patialiakas A., Thury A. et al. Zotarolimus-eluting versus bare-metal stents in uncertain drug-eluting stent candidates. J Am Coll Cardiol. 2015; 65(8): 805-815. doi: 10.1016/j.jacc.2014.11.053.</mixed-citation><mixed-citation xml:lang="en">Valgimigli M., Patialiakas A., Thury A. et al. Zotarolimus-eluting versus bare-metal stents in uncertain drug-eluting stent candidates. J Am Coll Cardiol. 2015; 65(8): 805-815. doi: 10.1016/j.jacc.2014.11.053.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ariotti S., Adamo M., Costa F. et al. Is Bare-Metal Stent Implantation Still Justifiable in High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention?: A Pre-Specified Analysis From the ZEUS Trial. JACC Cardiovasc Interv. 2016; 9(5): 426-436. doi: 10.1016/ j.jcin.2015.11.015.</mixed-citation><mixed-citation xml:lang="en">Ariotti S., Adamo M., Costa F. et al. Is Bare-Metal Stent Implantation Still Justifiable in High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention?: A Pre-Specified Analysis From the ZEUS Trial. JACC Cardiovasc Interv. 2016; 9(5): 426-436. doi: 10.1016/ j.jcin.2015.11.015.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Steffel J., Verhamme P., Potpara T.S. et al. The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. Eur Heart J. 2018; 39(16): 1330-1393. doi: 10.1093/eurheartj/ehy136.</mixed-citation><mixed-citation xml:lang="en">Steffel J., Verhamme P., Potpara T.S. et al. The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. Eur Heart J. 2018; 39(16): 1330-1393. doi: 10.1093/eurheartj/ehy136.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mehta S.R., Bainey K.R., Cantor W.J. 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy. Can J Cardiol. 2018; 34(3): 214-233. doi: 10.1016/j.cjca.2017.12.012.</mixed-citation><mixed-citation xml:lang="en">Mehta S.R., Bainey K.R., Cantor W.J. 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy. Can J Cardiol. 2018; 34(3): 214-233. doi: 10.1016/j.cjca.2017.12.012.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Alexander J.H., Becker R.C., Bhatt D.L. et al. Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial. Circulation. 2009; 119(22): 2877-2885. doi: 10.1161/circulationaha.108.832139.</mixed-citation><mixed-citation xml:lang="en">Alexander J.H., Becker R.C., Bhatt D.L. et al. Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial. Circulation. 2009; 119(22): 2877-2885. doi: 10.1161/circulationaha.108.832139.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Mega J.L., Braunwald E., Mohanavelu S. et al. Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, doubleblind, phase II trial. Lancet. 2009; 374(9683): 29-38. doi: 10.1016/S0140-6736(09)60738-8.</mixed-citation><mixed-citation xml:lang="en">Mega J.L., Braunwald E., Mohanavelu S. et al. Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, doubleblind, phase II trial. Lancet. 2009; 374(9683): 29-38. doi: 10.1016/S0140-6736(09)60738-8.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Oldgren J., Budaj A., Granger C.B. et al. Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial. Eur Heart J. 2011; 32(22): 2781-2789. doi: 10.1093/eurheartj/ehr113.</mixed-citation><mixed-citation xml:lang="en">Oldgren J., Budaj A., Granger C.B. et al. Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial. Eur Heart J. 2011; 32(22): 2781-2789. doi: 10.1093/eurheartj/ehr113.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Steg P.G., Mehta S.R., Jukema J.W. et al. RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome. Eur Heart J. 2011; 32(20): 2541-2554. doi: 10.1093/eurheartj/ehr334.</mixed-citation><mixed-citation xml:lang="en">Steg P.G., Mehta S.R., Jukema J.W. et al. RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome. Eur Heart J. 2011; 32(20): 2541-2554. doi: 10.1093/eurheartj/ehr334.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Alexander J.H., Lopes R.D., James S. et al. Apixaban with antiplatelet therapy after acute coronary syndrome. N Engl J Med. 2011; 365(8): 699-708. doi: 10.1056/NEJMoa1105819.</mixed-citation><mixed-citation xml:lang="en">Alexander J.H., Lopes R.D., James S. et al. Apixaban with antiplatelet therapy after acute coronary syndrome. N Engl J Med. 2011; 365(8): 699-708. doi: 10.1056/NEJMoa1105819.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Mega J.L., Braunwald E., Wiviott S.D. et al. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med. 2012; 366(1): 9-19. doi: 10.1056/NEJMoa1112277.</mixed-citation><mixed-citation xml:lang="en">Mega J.L., Braunwald E., Wiviott S.D. et al. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med. 2012; 366(1): 9-19. doi: 10.1056/NEJMoa1112277.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Bayer A.G. Xarelto Summary of Product Characteristics. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000944/WC500057108.pdf. Accessed June 28, 2018.</mixed-citation><mixed-citation xml:lang="en">Bayer A.G. Xarelto Summary of Product Characteristics. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000944/WC500057108.pdf. Accessed June 28, 2018.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Gibson C.M., Pinto D.S., Chi G. et al. Recurrent Hospitalization Among Patients With Atrial Fibrillation Undergoing Intracoronary Stenting Treated With 2 Treatment Strategies of Rivaroxaban or a Dose-Adjusted Oral Vitamin K Antagonist Treatment Strategy. Circulation. 2017; 135(4): 323-333. doi: 10.1161/circulationaha.116.025783.</mixed-citation><mixed-citation xml:lang="en">Gibson C.M., Pinto D.S., Chi G. et al. Recurrent Hospitalization Among Patients With Atrial Fibrillation Undergoing Intracoronary Stenting Treated With 2 Treatment Strategies of Rivaroxaban or a Dose-Adjusted Oral Vitamin K Antagonist Treatment Strategy. Circulation. 2017; 135(4): 323-333. doi: 10.1161/circulationaha.116.025783.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Kerneis M., Gibson C.M., Chi G. et al. Effect of Procedure and Coronary Lesion Characteristics on Clinical Outcomes Among Atrial Fibrillation Patients Undergoing Percutaneous Coronary Intervention: Insights From the PIONEER AF-PCI Trial. JACC Cardiovasc Interv. 2018; 11(7): 626-634. doi: 10.1016/j.jcin.2017.11.009.</mixed-citation><mixed-citation xml:lang="en">Kerneis M., Gibson C.M., Chi G. et al. Effect of Procedure and Coronary Lesion Characteristics on Clinical Outcomes Among Atrial Fibrillation Patients Undergoing Percutaneous Coronary Intervention: Insights From the PIONEER AF-PCI Trial. JACC Cardiovasc Interv. 2018; 11(7): 626-634. doi: 10.1016/j.jcin.2017.11.009.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Cannon C.P, Bhatt D.L., Oldgren J. et al. Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation. N Engl J Med. 2017; 377(16): 1513-1524. doi: 10.1056/NEJMoa1708454.</mixed-citation><mixed-citation xml:lang="en">Cannon C.P, Bhatt D.L., Oldgren J. et al. Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation. N Engl J Med. 2017; 377(16): 1513-1524. doi: 10.1056/NEJMoa1708454.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Jackson L.R. 2nd, Ju C., Zettler M. et al. Outcomes of Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention Receiving an Oral Anticoagulant and Dual Antiplatelet Therapy: A Comparison of Clopidogrel Versus Prasugrel From the TRANS-LATE-ACS Study. JACC Cardiovasc Interv. 2015; 8(14): 1880-1889. doi: 10.1016/j.jcin.2015.08.018.</mixed-citation><mixed-citation xml:lang="en">Jackson L.R. 2nd, Ju C., Zettler M. et al. Outcomes of Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention Receiving an Oral Anticoagulant and Dual Antiplatelet Therapy: A Comparison of Clopidogrel Versus Prasugrel From the TRANS-LATE-ACS Study. JACC Cardiovasc Interv. 2015; 8(14): 1880-1889. doi: 10.1016/j.jcin.2015.08.018.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Ohman E.M., Roe M.T., Steg P.G. et al. Clinically significant bleeding with low-dose rivaroxaban versus aspirin, in addition to P2Y12 inhibition, in acute coronary syndromes (GEMINI-ACS-1): a double-blind, multicentre, randomised trial. Lancet. 2017; 389(10081): 1799-1808. doi: 10.1016/S0140-6736(17)30751-1.</mixed-citation><mixed-citation xml:lang="en">Ohman E.M., Roe M.T., Steg P.G. et al. Clinically significant bleeding with low-dose rivaroxaban versus aspirin, in addition to P2Y12 inhibition, in acute coronary syndromes (GEMINI-ACS-1): a double-blind, multicentre, randomised trial. Lancet. 2017; 389(10081): 1799-1808. doi: 10.1016/S0140-6736(17)30751-1.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Breet N.J., van Werkum J.W., Bouman H.J. et al. Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. JAMA. 2010; 303(8): 754-762. doi: 10.1001/jama.2010.181.</mixed-citation><mixed-citation xml:lang="en">Breet N.J., van Werkum J.W., Bouman H.J. et al. Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. JAMA. 2010; 303(8): 754-762. doi: 10.1001/jama.2010.181.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
