vestarВестник аритмологииJournal of Arrhythmology1561-86412658-7327НАО «Инкарт»10.35336/VA-2019-4-21-31vestar-180Research ArticleОБЗОРЫREVIEWSРоль аутоантител против антигенов кардиомиоцитов в развитии нарушений ритма сердца и внезапной сердечной смертиRole of autoantibodies against cardiomyocyte antigens in the development of cardiac arrhythmiae and sudden cardiac deathРябковаВ. А.RyabkovaV. A.

Рябкова Варвара Александровна

199034, Санкт-Петербург, Университетская наб., д. 7-9

Ryabkova Varvara Aleksandrovna

199034, Universitetskaya Embankment, 7-9, St. Petersburg

varvara-ryabkova@yandex.ruЧуриловЛ. П.ChurilovL. P.

199034, Санкт-Петербург, Университетская наб., д. 7-9

199034, Universitetskaya Embankment, 7-9, St. Petersburg

ШубикЮ. В.ShubikYu. V.

199034, Санкт-Петербург, Университетская наб., д. 7-9

199034, Universitetskaya Embankment, 7-9, St. Petersburg

Санкт-Петербургский государственный университетРоссияSt. Petersburg State UniversityRussian Federation2019200220202642131Copyright © Рябкова В.А., Чурилов Л.П., Шубик Ю.В., 20202020Рябкова В.А., Чурилов Л.П., Шубик Ю.В.Ryabkova V.A., Churilov L.P., Shubik Y.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestar.elpub.ru/jour/article/view/180

Приведены данные клинических и экспериментальных исследований о распространенности некоторых антимиокардиальных аутоантител среди пациентов с различными заболеваниями сердца и их патогенетической значимости; предложена классификация этих аутоантител, проанализированы их молекулярные и клеточные эффекты.

In this review we analyze clinical and experimental studies that elucidate the prevalence of some antimyocardial autoantibodies in patients with different heart diseases and their mechanistical relevance. We propose a classification of these autoantibodies and focus on their molecular and cellular effects.

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The authors declare that there are no conflicts of interest present.