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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vestar</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник аритмологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Arrhythmology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-8641</issn><issn pub-type="epub">2658-7327</issn><publisher><publisher-name>НАО «Инкарт»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35336/VA-2020-2-40-44</article-id><article-id custom-type="elpub" pub-id-type="custom">vestar-251</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Перспективы неинвазивной аблации желудочковых тахикардий у больных со структурной патологией сердца</article-title><trans-title-group xml:lang="en"><trans-title>Prospects for noninvasive ablation of ventricular tachycardia in patients with structural heart disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Королев</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korolev</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Королев Сергей Владимирович</p></bio><bio xml:lang="en"><p>Sergey Korolev</p></bio><email xlink:type="simple">sergejkorolev@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Троицкий</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Troitskiy</surname><given-names>A. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хабазов</surname><given-names>Р. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Khabazov</surname><given-names>R. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Восканян</surname><given-names>С. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Voskanyan</surname><given-names>S. E.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зотов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Zotov</surname><given-names>A. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вачев</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vachev</surname><given-names>S. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий» ФМБА России<country>Россия</country></aff><aff xml:lang="en">FSBI “Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies” FMBA of Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБУ «Государственный научный центр Российской Федерации - Федеральный медицинский биофизический центр имени А.И.Бурназяна» ФМБА России<country>Россия</country></aff><aff xml:lang="en">FSBI “State Scientific Center of the Russian Federation - Federal Medical Biophysical Center named after A.I.Burnazyan” FMBA of Russia<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>24</day><month>07</month><year>2020</year></pub-date><volume>27</volume><issue>2</issue><fpage>40</fpage><lpage>44</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Королев С.В., Троицкий А.В., Хабазов Р.И., Восканян С.Э., Зотов А.С., Вачев С.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Королев С.В., Троицкий А.В., Хабазов Р.И., Восканян С.Э., Зотов А.С., Вачев С.А.</copyright-holder><copyright-holder xml:lang="en">Korolev S.V., Troitskiy A.V., Khabazov R.I., Voskanyan S.E., Zotov A.S., Vachev S.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestar.elpub.ru/jour/article/view/251">https://vestar.elpub.ru/jour/article/view/251</self-uri><abstract><p>Описываются методы неинвазивной протонно-лучевой аблации аритмогенного субстрата желудочковых тахикардий у больных со структурной патологией сердца направленные на устранение триггеров и/или разрушение re-entry механизмов при помощи пучка протонов.</p></abstract><trans-abstract xml:lang="en"><p>The method of non-invasive proton-beam ablation of an arrhythmogenic substrate of ventricular tachycardia in patients with structural heart disease is aimed at eliminating triggers and/or destroying re-entry mechanisms using a proton beam described.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>желудочковая тахикардия</kwd><kwd>протонная терапия</kwd><kwd>неинвазивная аблация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ventricular tachycardia</kwd><kwd>proton therapy</kwd><kwd>non-invasive ablation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">McNally B, Robb R, Mehta M, et al. Out-of-hospital cardiac arrest surveillance Cardiac Arrest Registry to Enhance Survival (CARES), United States, October 1, 2005 -December 31, 2010. CDC [Internet]. 2011 Jul. Available from: https://www.cdc.gov/mmwr/preview/mmwrhtml/ss6008a1.htm.</mixed-citation><mixed-citation xml:lang="en">McNally B, Robb R, Mehta M, et al. Out-of-hospital cardiac arrest surveillance Cardiac Arrest Registry to Enhance Survival (CARES), United States, October 1, 2005 -December 31, 2010. CDC [Internet]. 2011 Jul. Available from: https://www.cdc.gov/mmwr/preview/mmwrhtml/ss6008a1.htm.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Tang P, Shenasa M, Boyle N. Ventricular arrhythmias and sudden cardiac death. Card Electrophysiol Clin. 2017;9(4):693-708. DOI: m.1016/j.ccep.2017.08.004.</mixed-citation><mixed-citation xml:lang="en">Tang P, Shenasa M, Boyle N. Ventricular arrhythmias and sudden cardiac death. Card Electrophysiol Clin. 2017;9(4):693-708. DOI: m.1016/j.ccep.2017.08.004.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Moss AJ, Zareba W, Hall WJ, et al. Multicenter automatic defibrillator implantation trial II investigators prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl JMed. 2004; 346:877-883. DOI: 10.1056/NEJMoa013474</mixed-citation><mixed-citation xml:lang="en">Moss AJ, Zareba W, Hall WJ, et al. Multicenter automatic defibrillator implantation trial II investigators prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl JMed. 2004; 346:877-883. DOI: 10.1056/NEJMoa013474</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Aliot EM, Stevenson WG, Almendral-Garrote JM, et al. EHRA/HRS expert consensus on catheter ablation of ventricular arrhythmias. Heart Rhythm. 2009; 6:886-933. DOI: 10.1016/j.hrthm.2009.04.030.</mixed-citation><mixed-citation xml:lang="en">Aliot EM, Stevenson WG, Almendral-Garrote JM, et al. EHRA/HRS expert consensus on catheter ablation of ventricular arrhythmias. Heart Rhythm. 2009; 6:886-933. DOI: 10.1016/j.hrthm.2009.04.030.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Mallidi J, Nadkarni G, Berger R, et al. Meta-analysis of catheter ablation as an adjunct to medical therapy for treatment of ventricular tachycardia in patients with structural heart disease. Heart Rhythm. 2011; 8(4):503-10. DOI: 10.1016/j.hrthm.2010.12.015.</mixed-citation><mixed-citation xml:lang="en">Mallidi J, Nadkarni G, Berger R, et al. Meta-analysis of catheter ablation as an adjunct to medical therapy for treatment of ventricular tachycardia in patients with structural heart disease. Heart Rhythm. 2011; 8(4):503-10. DOI: 10.1016/j.hrthm.2010.12.015.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Cuculich PS, Schill MR, Kashani R, et al. Noninvasive cardiac radiation for ablation of ventricular tachycardia. N Engl J Med. 2017; 377:2325-2336/ DOI: 10.1056/NEJ-Moa1613773.</mixed-citation><mixed-citation xml:lang="en">Cuculich PS, Schill MR, Kashani R, et al. Noninvasive cardiac radiation for ablation of ventricular tachycardia. N Engl J Med. 2017; 377:2325-2336/ DOI: 10.1056/NEJ-Moa1613773.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Robinson C, Samson P, Moore K, et al. Phase I/II trial of electrophysiology-guided noninvasive cardiac radioablation for ventricular tachycardia. Circulation. 2019; 139(3):313-321. DOI: 10.1161/CIRCULATIONA-HA.118.038261.</mixed-citation><mixed-citation xml:lang="en">Robinson C, Samson P, Moore K, et al. Phase I/II trial of electrophysiology-guided noninvasive cardiac radioablation for ventricular tachycardia. Circulation. 2019; 139(3):313-321. DOI: 10.1161/CIRCULATIONA-HA.118.038261.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Silberbauer J. Future now: new technologies for treatment of ventricular tachycardia. Conference report. The Moscow international VT summit. October 2019. Available from: https://fnkc-fmba.ru/sobytiya/the-moscow-in-ternational-ventricular-tachycardia-summit.</mixed-citation><mixed-citation xml:lang="en">Silberbauer J. Future now: new technologies for treatment of ventricular tachycardia. Conference report. The Moscow international VT summit. October 2019. Available from: https://fnkc-fmba.ru/sobytiya/the-moscow-in-ternational-ventricular-tachycardia-summit.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Knutson NC, Samson PP, Hugo GD, et al. Radiation therapy workflow and dosimetric analysis from a phase 1/2 trial of noninvasive cardiac radioablation for ventricular tachycardia. JRadiat Oncol Biol Phys. 2019; 104(5):1114-1123. DOI: 10.1016/j.ijrobp.2019.04.005.</mixed-citation><mixed-citation xml:lang="en">Knutson NC, Samson PP, Hugo GD, et al. Radiation therapy workflow and dosimetric analysis from a phase 1/2 trial of noninvasive cardiac radioablation for ventricular tachycardia. JRadiat Oncol Biol Phys. 2019; 104(5):1114-1123. DOI: 10.1016/j.ijrobp.2019.04.005.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Graeff C, Bert C. Noninvasive cardiac arrhythmia ablation with particle beams. Med Phys. 2018; 45(11):1024-1035. DOI:10.1002/mp.12595.</mixed-citation><mixed-citation xml:lang="en">Graeff C, Bert C. Noninvasive cardiac arrhythmia ablation with particle beams. Med Phys. 2018; 45(11):1024-1035. DOI:10.1002/mp.12595.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mondlane G, Gubanski M, Lind PA, et al. Comparative study of the calculated risk of radiation-induced cancer after photon- and proton-beam based radiosurgery of liver metastases. Phys Med. 2017; 42:263-270. DOI: 10.1016/j.ejmp.2017.03.019.</mixed-citation><mixed-citation xml:lang="en">Mondlane G, Gubanski M, Lind PA, et al. Comparative study of the calculated risk of radiation-induced cancer after photon- and proton-beam based radiosurgery of liver metastases. Phys Med. 2017; 42:263-270. DOI: 10.1016/j.ejmp.2017.03.019.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Wilson RR, Radiological use of fast protons. Radiology. 1946; 47:487-491; DOI: 10.1148/47.5.487.</mixed-citation><mixed-citation xml:lang="en">Wilson RR, Radiological use of fast protons. Radiology. 1946; 47:487-491; DOI: 10.1148/47.5.487.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Goddu SM, Hilliard J, Knutson N, et al. Feasibility of noninvasive cardiac ablation utilizing intensity modulated proton therapy to treat ventricular tachycardia. International Journal of Radiation Oncology Biology Physics. 2018; 102(3):58. DOI:10.1016/j.ijrobp.2018.06.166.</mixed-citation><mixed-citation xml:lang="en">Goddu SM, Hilliard J, Knutson N, et al. Feasibility of noninvasive cardiac ablation utilizing intensity modulated proton therapy to treat ventricular tachycardia. International Journal of Radiation Oncology Biology Physics. 2018; 102(3):58. DOI:10.1016/j.ijrobp.2018.06.166.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Hohmann S, Deisher AJ, Suzuki A, et al. Left ventricular function after noninvasive cardiac ablation using proton beam therapy in a porcine model. Heart Rhythm, 2019; 16(11):1710-1719. DOI: 10.1016/j.hrthm.2019.04.030.</mixed-citation><mixed-citation xml:lang="en">Hohmann S, Deisher AJ, Suzuki A, et al. Left ventricular function after noninvasive cardiac ablation using proton beam therapy in a porcine model. Heart Rhythm, 2019; 16(11):1710-1719. DOI: 10.1016/j.hrthm.2019.04.030.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Lehmann HI, Deisher AJ, Takami M, et al. External arrhythmia ablation using photon beams: ablation of the atrioventricular junction in an intact animal model. Circ Arrhythm Electrophysiol. 2017;10(4). DOI:10.1161/CIR-CEP.116.004304.</mixed-citation><mixed-citation xml:lang="en">Lehmann HI, Deisher AJ, Takami M, et al. External arrhythmia ablation using photon beams: ablation of the atrioventricular junction in an intact animal model. Circ Arrhythm Electrophysiol. 2017;10(4). DOI:10.1161/CIR-CEP.116.004304.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Suit H, DeLaney T, Goldberg S, et al. Proton vs carbon ion beams in the definitive radiation treatment of cancer patients. Radiother Oncol. 2010; 95(1):3-22. DOI: 10.1016/j.radonc.2010.01.015.</mixed-citation><mixed-citation xml:lang="en">Suit H, DeLaney T, Goldberg S, et al. Proton vs carbon ion beams in the definitive radiation treatment of cancer patients. Radiother Oncol. 2010; 95(1):3-22. DOI: 10.1016/j.radonc.2010.01.015.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Bao C, Sun Y, Dong Y. et al. The relative biological effectiveness of proton and carbon ion beams in photon-sensitive and resistant nasopharyngeal cancer cells. Translational Cancer Research, 2018; 7(1):170-179. DOI: 10.21037/tcr.2018.01.25.</mixed-citation><mixed-citation xml:lang="en">Bao C, Sun Y, Dong Y. et al. The relative biological effectiveness of proton and carbon ion beams in photon-sensitive and resistant nasopharyngeal cancer cells. Translational Cancer Research, 2018; 7(1):170-179. DOI: 10.21037/tcr.2018.01.25.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Lehmann HI, Graeff C, Simoniello P, et al. Feasibility study on cardiac arrhythmia ablation using high-energy heavy ion beams. Scientific Reports, 2016; 6: Article number: 38895. DOI: 10.1038/srep3889515.</mixed-citation><mixed-citation xml:lang="en">Lehmann HI, Graeff C, Simoniello P, et al. Feasibility study on cardiac arrhythmia ablation using high-energy heavy ion beams. Scientific Reports, 2016; 6: Article number: 38895. DOI: 10.1038/srep3889515.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Dixon-Altaber H. CERN congratulates CNAO on a world’s first proton treatment of a cardiac pathology [Internet]. Available from: https://home.cern/news/news/knowledge-sharing/cern-congratulates-cn-ao-worlds-first-proton-treatment-cardiac-pathology?f-bclid=IwAR0SuY5ybzTuHdjdIS0EPLhjVgjnw1k_in-adHz9EnY8EzzRZ0U5sApwc5vM.</mixed-citation><mixed-citation xml:lang="en">Dixon-Altaber H. CERN congratulates CNAO on a world’s first proton treatment of a cardiac pathology [Internet]. Available from: https://home.cern/news/news/knowledge-sharing/cern-congratulates-cn-ao-worlds-first-proton-treatment-cardiac-pathology?f-bclid=IwAR0SuY5ybzTuHdjdIS0EPLhjVgjnw1k_in-adHz9EnY8EzzRZ0U5sApwc5vM.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma A, Wong D, Weidlich G, et al. Noninvasive stereotactic radiosurgery (CyberHeart) for creation of ablation lesions in the atrium. Heart Rhythm, 2010; 7(6):802-10. DOI: 10.1016/j.hrthm.2010.02.010.</mixed-citation><mixed-citation xml:lang="en">Sharma A, Wong D, Weidlich G, et al. Noninvasive stereotactic radiosurgery (CyberHeart) for creation of ablation lesions in the atrium. Heart Rhythm, 2010; 7(6):802-10. DOI: 10.1016/j.hrthm.2010.02.010.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Blanck O, Bode F, Gebhard M, et al. Dose-escalation study for cardiac radiosurgery in a porcine model. Int J Radiat Oncol Biol Phys, 2014; 89(3):590-8. DOI: 10.1016/j.ijrobp.2014.02.036.</mixed-citation><mixed-citation xml:lang="en">Blanck O, Bode F, Gebhard M, et al. Dose-escalation study for cardiac radiosurgery in a porcine model. Int J Radiat Oncol Biol Phys, 2014; 89(3):590-8. DOI: 10.1016/j.ijrobp.2014.02.036.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med, 2013; 368:987-998. DOI: 10.1056/NEJMoa1209825.</mixed-citation><mixed-citation xml:lang="en">Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med, 2013; 368:987-998. DOI: 10.1056/NEJMoa1209825.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
