EFFECT OF LIPOPHILIC AND HYDROPHILIC BETA-ADRENOBLOCKERS ON THE CHRONOTROPIC CARDIAC FUNCTION
Abstract
In experiments on anesthetized rats, the effect was studied of intra-cisternal and intra-peritoneal administration of Propranolol and Sotalol on the heart rate variability.
About the Authors
N. V. Kaverina
ГУ НИИ фармакологии им. В.В.Закусова РАМН, Российский Кардиологический Научно-производственный комплекс МЗ РФ, Москва
Russian Federation
Russian Federation
V. V. Lyskovtsev
ГУ НИИ фармакологии им. В.В.Закусова РАМН, Российский Кардиологический Научно-производственный комплекс МЗ РФ, Москва
Russian Federation
Russian Federation
E. P. Popova
ГУ НИИ фармакологии им. В.В.Закусова РАМН, Российский Кардиологический Научно-производственный комплекс МЗ РФ, Москва
Russian Federation
Russian Federation
M. A. Lebedeva
ГУ НИИ фармакологии им. В.В.Закусова РАМН, Российский Кардиологический Научно-производственный комплекс МЗ РФ, Москва
Russian Federation
Russian Federation
E. V. Lukoshkova
ГУ НИИ фармакологии им. В.В.Закусова РАМН, Российский Кардиологический Научно-производственный комплекс МЗ РФ, Москва
Russian Federation
Russian Federation
References
1. Hedman A.E., Tahvanainejnen K.U. et al. Effects of sympathetic modulation and sympato-vagal interaction on heart rate variability in anaesthetized dogs. Act. Phisiol. Scand., 1995, v.151, p.205-214.
2. Malliani A. Low frequency components of cardiovascular variabilities as markers of sympathetic modulation. Trends in Physiol. Sci., 1992, 13, р.50-54.
3. Malliani A. The pattern of sympathovagal balance explored in frequency domain. News Phisiol. Sci., 1999, 14, р.111-117.
4. Ochs R.A., Greenblatt D.J. Single-dose kinetics of oral Propranolol Metoprolol, Atenolol and Sotalol: relation of lipophility. Arzneim-Forsh. Drug Res., 1985, 35,II, 10, р.1580.
5. Parker GW., Michael LH., Hortly CY., Skinner YE., Entman ML. Central P-adrenegic mechanisms may modulate ishemic ventricular fibrillation in pigs. Circ.Res., 1990, v.5, 66, р.259-267.
6. Randal D.C., Brown D.R. et all. Interaction within the intrinsic cardiac nervous system contribute to chronotropic regulation. Am. J. Physiol. Regular. Interzg. Comp. Physiol. 2003, 285 (5), R. Р.1066-75.
7. Vaile JC., Fletcher J., Al-Ani et al. Use of opposing reflex stimuli and heart rate variability to examine the effects of lipophilic and hydrophilic P-blockers on human cardiac vagal control. Clin. Sci., 1999, 97, р.585-593.
Review
For citations:
Kaverina N.V., Lyskovtsev V.V., Popova E.P., Lebedeva M.A., Lukoshkova E.V. EFFECT OF LIPOPHILIC AND HYDROPHILIC BETA-ADRENOBLOCKERS ON THE CHRONOTROPIC CARDIAC FUNCTION. Journal of Arrhythmology. 2007;(50):29-32. (In Russ.)
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