ROLE OF BETA-ADRENOBLOCKERS IN PREVENTION OF CARDIAC ARRHYMIAS INCLUDING VENTRICULAR FIBRILLATION IN RAT MYOCARDIAL ISCHEMIA CAUSED BY OCCLUSION OF CORONARY ARTERY
Abstract
To compare the effectiveness and mechanisms of action of the lipophilic β adrenoblocker Propranolol and the hydrophilic β adrenoblocker Sotalol in the case of ventricular arrhythmias and ventricular fibrillation caused by occlusion of the left descending coronary artery, the experiment was performed on urethan anesthetized mongrel rats of body mass of 150 250 g under artificial pulmonary ventilation.
About the Authors
N. V. Kaverina
ГУ НИИ фармакологии им. В.В.Закусова РАМН, Москва, Россия
Russian Federation
Russian Federation
V. V. Lyskovtsev
ГУ НИИ фармакологии им. В.В.Закусова РАМН, Москва, Россия
Russian Federation
Russian Federation
M. A. Lebedeva
ГУ НИИ фармакологии им. В.В.Закусова РАМН, Москва, Россия
Russian Federation
Russian Federation
E. P. Popova
ГУ НИИ фармакологии им. В.В.Закусова РАМН, Москва, Россия
Russian Federation
Russian Federation
References
1. Каверина Н.В., Лысковцев В.В., Попова Е.П. и др. Влияние липофильных и гидрофильных бета-блокаторов пропранолола и соталола на хронотропную функцию сердца // Вестник Аритмологии, 2008.
2. Ablad B., Biurö T., Björkman JA., Edström., Olison G. Role of central nervous system in the prevention of ventricular fibrillation through augmentation of cardiac vagal tone. // J Am Coll Cardial., 1991, 17 (Supple 165).
3. Eckberg DE. Vagal effects of lipophilic and hydrophilic beta-adrenergic blocking drugs. // J Clinical Science, 1999, 97, 607-610. Механизм, с которым связана высокая эффективность пропранолола в предупреждении фибрилляции желудочков обусловлен активацией вагусного контроля сердца.
4. Huikuri HV., Cox M., Interian AJr., Kessler KM et al. Efficacy of intravenous propranolol for suppression of inducibility of ventricular tachiarrhythmia with different electrophysiological characteristics in coronary artery disease. // Am J Cardiol., 1989, 64 1305-9.
5. Metoprolol in acute myocardial infarction (MJAMJ). A randomized placebo-controlled international trial. The MJAMJ Trial Research Group. // Eur Heart J.
6. Olson G., Wikstrand J., Warnold I., et al. Metoprolol-induced reduction in post-infarction mortality: pooled results from five double-blind randomized trials. // Eur Heart J, 1992.
7. Parker GW., Michael LH., Harthley CY. Central beta-adrenergic mechanisms may modulated ischemia ventricular fibrillation in pigs. // Circ Res, 1990, 60, 259-70.
8. Rajman J., Kendall MJ. Sudden cardiac death and the potential role of beta-blockers. // Postgrad Med J, 1993, 69, 903-1.
9. The Cardiac Arrhythmia Suppression Trial (CAST) investigators. // N Eng. J Med., 1989, 321: 406-12.
10. The Cardiac Arrhythmia Suppression Trial II (CAST II) investigators. // N Eng. J Med., 1992, 327: 227-33.
11. Wikstrand J and Kandall M. The role of beta-receptor blocked in preventing sudden death. // Eur Heart J, 1992, 13 (Supple D):III-20.
12. Yusuf S., Peto R., Levis J. et al. Beta-blocking during and after myocardial infarction: an overview of the randomized trials. // Prog. Cardiovasc Dis., 1985, 27, 335-71.
Review
For citations:
Kaverina N.V., Lyskovtsev V.V., Lebedeva M.A., Popova E.P. ROLE OF BETA-ADRENOBLOCKERS IN PREVENTION OF CARDIAC ARRHYMIAS INCLUDING VENTRICULAR FIBRILLATION IN RAT MYOCARDIAL ISCHEMIA CAUSED BY OCCLUSION OF CORONARY ARTERY. Journal of Arrhythmology. 2008;52(52):63-65. (In Russ.)
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