ARRHYTHMOGENIC RIGHT VENTRICLE DYSPLASIA AND VIRAL INFECTION: POTENTIAL COMBINATIONS AND ROLE IN DEVELOPMENT OF VENTRICULAR ARRHYTHMIAS
Abstract
To reveal morphological markers of both hereditary and acquired alterations in patients with the arrhythmogenic right ventricle dysplasia, endocardial biopsy samples of 57 patients with ventricular arrhythmias (37 women, 20 men, age 48±12 years) and autopsy samples of 2 subjects (a 43 year old female and a 69 year old male) suddenly deceased due to ventricular fibrillation were assessed.
About the Authors
L. B. Mitrofanova
ФГУ «ФЦ сердца, крови и эндокринологии им. В.А. Алмазова», Санкт-Петербург
Russian Federation
Russian Federation
O. V. Beshchuk
ФГУ «ФЦ сердца, крови и эндокринологии им. В.А. Алмазова», Санкт-Петербург
Russian Federation
Russian Federation
R. B. Tatarsky
ФГУ «ФЦ сердца, крови и эндокринологии им. В.А. Алмазова», Санкт-Петербург
Russian Federation
Russian Federation
D. S. Lebedev
ФГУ «ФЦ сердца, крови и эндокринологии им. В.А. Алмазова», Санкт-Петербург
Russian Federation
Russian Federation
References
1. Basso C., Thiene G., Corrado D. et al. Arrhythmogenic right ventricular cardiomyopathy. Dysplasia, dystrophy or myocarditis? // Circulation. - 1996. - Vol. 94. - P.983-991.
2. Bowles N.E., Ni J., Marcus F., Towbin J. The detection of cardiotropic viruses in the myocardium of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy // J Am Coll Cardiol. - 2002. - Vol. 39. - P.892-895.
3. Calabrese F., Basso C., Carturan E. et al. Arrhythmogenic right ventricular cardiomyopathy/ dysplasia: is there a role for viruses? // Cardiovascular Pathology - 2006. -Vol. 15. - P.11-17.
4. Calkins H. Arrhythmogenic right ventricular dysplasia // Trans Am Clin Climatol Assoc. - 2008. - Vol.119. - P.273-288.
5. Duechting A., Tschöpe C., Kaiser H. et al. Human parvovirus B19 NS1 protein modulates inflammatory signaling by Activation of STAT3/PIAS3 in human endothelial cells // J Virol. - 2008. - Vol.86. - P.7942-7952.
6. Fontaine G., Fontaliran F., Zenati O. et al. Fat in the heart. A feature unique to the human species? Observational reflections on an unsolved problem // Acta Cardiol. - 1999. - Vol.54. - P. 189-194.
7. Fontaine G., Mallat Z., Fornes P., et al. Etiopathogenesis of arrhythmogenic right ventricular dysplasia // Ann Cardiol Angeiol (Paris). - 2000. - Vol. 49. - P.37-47.
8. Franssila R., Auramo J., Modrow S. et al. T-helper cell - mediated interferon - gamma expression after human parvovirus B19 infection: persisting VP2-specific and transient VP1u-specific activity // Clin Exp Immunol. - 2005. - Vol. 142. - P. 53-61.
9. Heuser A., Plovie E.R., Ellionor P.T. et al. Mutant des-mocollin-2 causes arrhythmogenic right ventricular cardiomyopathy // Am J Hum Genet. - 2006. - Vol. 79. - P.1081-1088.
10. Kühl U., Pauschinger M., Noutsias M. et al. High prevalence of Viral Genomes and Multiple Viral Infections in the Myocardium of Adults with “idiopathic” left Ventricular Dysfunction // Circulation. - 2005. - Vol.111. - P.887-893.
11. Li D., Ahmad F., Gardner M.J. et al. The locus of a novel gene responsble for arrhythmogenic right-ventricular dysplasia characterized by early onset and high penetrance maps to chromosome 10p12-p14 // Am J Hum Genet. -2000. - Vol. 66. - P.148-156.
12. Lotkowski D., Grzybiak M., Kozlowski D. et al. A microscopic view of false tendons in the left ventricle of the human heart // Folia Morphol. - 1997. - Vol.56. - P. 31-39.
13. Maron B.J., Towbin J.A., Thiene G. et al. Contemporary Definitions and Classification of the Cardiomyopathies // Circulation. - 2006. - Vol.113. - P.1807-1816.
14. Nishikawa T., Ishiyama S., Nagata M. et al. Ptogrammed cell death in the myocardium of arrhythmogenic right ventricular cardiomyopathy in children and adults // Cardiovasc Pathol. - 1999. - Vol.8. - P.185-189.
15. Robert A., Miron M.J., Champagne C. et al. Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein // J Cell Biol. - 2002. - Vol.158. -P.519-528.
16. Shtrichman R., Sharf R., Barr H. et al. Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A // Proc Natl Acad Sci USA. - 1999. - Vol.96. - P.10080-10085.
17. Song Z.Z. A combination of right ventricular hypertrabeculation/noncompaction and arrhythmogenic right ventricular cardiomyopathy: a syndrome? // Cardiovasc Ultrasound. - 2008. - Vol. 6. - P.63-66.
18. Tabib A., Loire R., Chalabreysse L. et al. Circumstances of death and gross and microscopic observations in a series of 200 cases of sudden death associated with arrhythmogenic right ventricular cardiomyopathy and/or dysplasia // Circulation. - 2003. - Vol.108. - P.3000-3005.
19. Thiene G., Corrado D., Basso C. Arrhythmogenic right ventricular cardiomyopathy/ dysplasia // Orphanet J Rare Dis. - 2007. - Vol.14. - P.2-45.
20. van Kuppeveld F.J., Hoenderop J.G., Smeets R.L. et al. Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release // EMBO J. - 1997. - Vol.12. - P.3519-3532
Review
For citations:
Mitrofanova L.B., Beshchuk O.V., Tatarsky R.B., Lebedev D.S. ARRHYTHMOGENIC RIGHT VENTRICLE DYSPLASIA AND VIRAL INFECTION: POTENTIAL COMBINATIONS AND ROLE IN DEVELOPMENT OF VENTRICULAR ARRHYTHMIAS. Journal of Arrhythmology. 2009;(58):15-20. (In Russ.)
Views:
126
Email this article 