COMPOUND (-)-U-50,488 IMPROVES THE HEART TOLERANCE TO THE ARRHYTHMOGENIC EFFECT OF SHORT-TERM ISCHEMIA DUE TO ACTIVATION OF K1-OPIATE RECEPTORS
Abstract
To clarify the nature of the antiarrhythmic effect of U-50,488 in acute coronary occlusion and reperfusion modeled by the left coronary artery ligation, experiments were made on Wistar rats with body weight of 200-250 g narcotized with Ketamine (50 mg/kg intraperitoneally).
Keywords
U-50,
488,
coronary arteries,
ventricular arrhythmias,
ischemia,
reperfusion,
opiate receptors,
U-50,
488,
Wistar rats
About the Authors
L. N. Maslov
НИИ кардиологии ТНЦ СО РАМН; Томский гос. пед. Университет, Томск, Россия
Russian Federation
Russian Federation
A. Yu. Lishmanov
НИИ кардиологии ТНЦ СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Maslov L.N., Lishmanov A.Yu. COMPOUND (-)-U-50,488 IMPROVES THE HEART TOLERANCE TO THE ARRHYTHMOGENIC EFFECT OF SHORT-TERM ISCHEMIA DUE TO ACTIVATION OF K1-OPIATE RECEPTORS. Journal of Arrhythmology. 2010;60(60):59-64. (In Russ.)
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