CORRELATION OF POLYMORPHISM OF FIBRINOGEN BETA-CHAIN GENE AND STROKE IN FAMILIES OF PATIENTS WITH ATRIAL FIBRILLATION

O study the -455G>A gene polymorphism of the fibrinogen β-chain (FGB) in families of patients with atrial fibrillation (AF) and stroke, 43 probands with chronic AF and a history of stroke (25 women and 18 men) and their 56 relatives of degrees of kinship of grades I III (39 women and 17 men), as well as 153 subjects of the control group free of cardiovascular pathology (82 women and 71 men) were examined. The patients with stroke aged 63.7±18.86 years (45 85 years), their relatives aged 53.6±16.8 years (12 73 years), and the control group subjects, 52.4±16.4 years (45 69 years). In the study subjects, performed were assessment of complaints and the medical history, physical examination, electrocardiography, and echocardiography. The gene polymorphism was tested with the aid of polymerase chain reaction in the real time mode. A significant prevalence of the homozygous genotype AA was revealed in the patients with AF and stroke as compared with the control group (11.6% and 2.6%; p=0.037). A tendency to prevalence of the above genotype was noted in the relatives of patients with AF and stroke (8.9% and 2.5%; p=0.108). The prevalence of the AA genotype in the probands with AF and stroke and their relatives did not differ (11.6% and 8.9%; p=0.916). In the patients with AF and stroke, a considerable prevalence of the A allele as compared with the control group was revealed (32.6% and 19.6%; p=0.017). In the relatives of the patients with AF and stroke, Allele A was also revealed more frequently than in control group (30.4% and 19.6%; p=0.028). Thus, taking the results obtained into the account, an correlation of the genotype AA and allele A with stroke in the families of patients with AF and stroke was revealed.

A гена β-цепи фибриногена, варфарин, дабигатран, atrial fibrillation, stroke, fibrinogen, polymorphism of -455G>, A gene of the fibrinogen β-chain, Warfarin, Dabigartan

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