The role of high-density mapping in atrial fibrillation ablation
https://doi.org/10.35336/VA-2021-1-33-37
Abstract
Aims. To determine the role of the prevalence of low-voltage areas in the occurrence of arrhythmia recurrence after interventional treatment of atrial fibrillation (AF).
Methods. The study included 38 patients with paroxysmal (52.6%) and persistent (47.4%) forms of AF who underwent interventional treatment of AF using high-density electroanatomical mapping (at least 10,000 EGM points). Analysis of electroanatomical maps was performed after the completion of the ablation procedure. The area of the low-voltage zones was measured manually. Then, the areas of all regions of low-voltage activity were summed up; the resulting value was expressed as a percentage of the total surface area of the left atrium (LA).
Results. The observation period was 12.8±3.2 months. Based on the results of endocardial mapping, all patients were divided into 2 groups according to the prevalence of low-voltage areas in the LA. The first group included patients with an area of low-voltage zones less than 5% of the total surface of the left atrium, and the second with an area of low-voltage areas of more than 5% of the total surface of the left atrium. The patients of the first group had a lower LA volume compared to patients from the second group, with mean values of 119.87±16.35 ml and 154.57±33.23 ml, respectively (p=0.007). In the first group, AF recurrence was recorded in one patient after catheter treatment, in the second group in 5 patients.
Conclusion. Common areas of low-voltage activity in the left atrium, detected by high-density mapping before the procedure for catheter treatment of AF, are a predictor of arrhythmia recurrence after interventional treatment.
About the Authors
E. V. DedukhRussian Federation
Moscow
E. A. Artyukhina
Russian Federation
Moscow
References
1. Clinical practice guidelines for electrophysiological studies, catheter ablation and the use of implantable antiarrhythmic devices. 2017; p 701.
2. Toufan M, Kazemi B, Molazadeh N. The significance of the left atrial volume index in prediction of atrial fibrillation recurrence after electrical cardioversion. J Cardiovasc Thorac Res. 2017;9(1): 54-59. https://doi.org/10.15171/jcvtr.2017.08.
3. Hansen BJ, Zhao J, Csepe TA, et al. Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts. Eur Heart J. 2015;36(35): 2390-2401. https://doi.org/10.1093/eurheartj/ehv233.
4. Ling Z, McManigle J, Zipunnikov V, et al. The association of left atrial low-voltage regions on electroanatomic mapping with low attenuation regions on cardiac computed tomography perfusion imaging in patients with atrial fibrillation. Heart Rhythm. 2015;12(5): 857-864. https:// doi.org/10.1016/j.hrthm.2015.01.015.
5. Heijman J, Algalarrondo V, Voigt N, et al. The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis. Cardiovasc Res. 2016;109(4): 467-479. https://doi.org/10.1093/cvr/cvv275.
6. Zahid S, Cochet H, Boyle PM, et al. Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern. Cardiovasc Res. 2016;110(3): 443-454. https://doi.org/10.1093/cvr/cvw073.
7. Verma A, Wazni OM, Marrouche NF, et al. Pre-existent left atrial scarring in patients undergoing pulmonary vein antrum isolation: an independent predictor of procedural failure. J Am Coll Cardiol. 2005;45(2): 285-292. https://doi.org/10.1016/j.jacc.2004.10.035.
8. Begg GA, Karim R, Oesterlein T, et al. Left atrial voltage, circulating biomarkers of fibrosis, and atrial fibrillation ablation. A prospective cohort study. PLoS One. 2018;13(1): e0189936. Published 2018 Jan 2. https://doi.org/10.1371/journal.pone.0189936.
9. Nattel S, Harada M. Atrial remodeling and atrial fibrillation: recent advances and translational perspectives. J Am Coll Cardiol. 2014;63(22): 2335-2345. https://doi. org/10.1016/j.jacc.2014.02.555.
10. Pappone C, Oreto G, Rosanio S, et al. Atrial electroanatomic remodeling after circumferential radiofrequency pulmonary vein ablation: efficacy of an anatomic approach in a large cohort of patients with atrial fibrillation. Circulation. 2001;104(21): 2539-2544. https://doi.org/10.1161/hc4601.098517.
11. Spragg DD, Khurram I, Zimmerman SL, et al. Initial experience with magnetic resonance imaging of atrial scar and co-registration with electroanatomic voltage mapping during atrial fi success and limitations. Heart Rhythm. 2012;9(12): 2003-2009. https://doi.org/10.1016/j.hrthm.2012.08.039.
12. Molina CE, Abu-Taha IH, Wang Q, et al. Profibrotic, Electrical, and calcium-handling remodeling of the atria in heart failure patients with and without atrial fibrillation. Front Physiol. 2018;9: 1383. Published 2018 Oct 9. https://doi.org/10.3389/fphys.2018.01383.
13. Frangogiannis NG. Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities. Mol Aspects Med. 2019;65: 70-99. https://doi. org/10.1016/j.mam.2018.07.001.
14. Nattel S. How does fibrosis promote atrial fibrillation persistence: in silico findings, clinical observations, and experimental data. Cardiovasc Res. 2016;110(3): 295-297. https://doi.org/10.1093/cvr/cvw092.
15. Chen R, Wen C, Fu R, et al. The effect of complex intramural microstructure caused by structural remodeling on the stability of atrial fibrillation: Insights from a three-dimensional multi-layer modeling study. PLoS One. 2018;13(11): e0208029. Published 2018 Nov 28. https://doi.org/10.1371/journal.pone.0208029.
16. Marrouche NF, Brachmann J, Andresen D, et al. Catheter ablation for atrial fibrillation with heart failure. N Engl J Med. 2018;378(5): 417-427. https://doi.org/10.1056/NEJMoa1707855.
17. Staerk L, Sherer JA, Ko D, et al. Atrial Fibrillation: Epidemiology, Pathophysiology, and Clinical Outcomes. Circ Res. 2017;120(9): 1501-1517. https://doi.org/10.1161/CIRCRESAHA.117.309732.
18. Corradi D. Atrial fibrillation from the pathologist’s perspective. Cardiovasc Pathol. 2014;23(2): 71-84. https://doi.org/10.1016/j.carpath.2013.12.001.
19. van den Berg MP, Mulder BA, Klaassen SHC, et al. Heart failure with preserved ejection fraction, atrial fi and the role of senile amyloidosis. Eur Heart J. 2019;40(16): 1287-1293. https://doi.org/10.1093/eurheartj/ehz057.
Review
For citations:
Dedukh E.V., Artyukhina E.A. The role of high-density mapping in atrial fibrillation ablation. Journal of Arrhythmology. 2021;28(1):33-37. (In Russ.) https://doi.org/10.35336/VA-2021-1-33-37