УРОВЕНЬ ТЕСТОСТЕРОНА В КАЧЕСТВЕ ПРЕДИКТОРА ОТВЕТА НА СЕРДЕЧНУЮ РЕСИНХРОНИЗИРУЮЩУЮ ТЕРАПИЮ

С целью изучения взаимосвязи уровня тестостерона с эффективностью сердечной ресинхронизирующей терапии у мужчин с хронической сердечной недостаточностью II-IV функционального класса по классификации NYHA обследованы 58 пациентов (средний возраст 54,8±9,6 года).

хроническая сердечная недостаточность, сердечная ресинхронизирующая терапия, тестостерон, эхокардиография, цитокины, матриксная металлопротеиназа 9, ингибиторы мат-риксных металлопротеиназ 1 и 4, галектин 3

1. Meyer S., van der Meer P., van Deursen V.M. et al. Neurohormonal and clinical sex differences in heart failure.// European Heart Journal. 2013; 34:2538-2547.

2. Kloner R.A., Carson C. 3rd, Dobs A. et al. Testosterone and Cardiovascular Disease. //J Am Coll Cardiol. 2016 Feb 9;67(5):545-57.

3. Sacca L. Heart failure as a multiple hormonal deficiency syndrome. // Circulation 2009;2:151- 6.

4. Muraleedharan V, Jones T.H. Testosterone and mortality.// Clin Endocrinol (Oxf). 2014 Oct;81(4):477-87.

5. Jankowska E.A., Tkaczyszyn M., Kalicinska E. et al. Testosterone deficiency in men with heart failure: pathophysiology and its clinical, prognostic and therapeutic implication. // Kardiologia Polska. 2014;72(5):403-409.

6. Jankowska E.A., Filippatos G., Ponikowska B., et al. Reduction in circulating testosterone relates to exercise capacity in men with chronic heart failure. // Journal of Cardiac Failure. 2009;15(5):442-450.

7. Rydlewska A., Maj J., Katkowski B. et al. // Circulating testosterone and estradiol, autonomic balance and baroreflex sensitivity in middle-aged and elderly men with heart failure. Aging Male. 2013;16(2):58-66.

8. Kim C., Cushman M., Kleindorfer D. et al. A Review of the Relationships Between Endogenous Sex Steroids and Incident Ischemic Stroke and Coronary Heart Disease Events. // Curr Cardiol Rev. 2015 Aug; 11(3): 252-260.

9. Santos M.R., Sayegh A.L., Groehs R.V. et al. Testosterone deficiency increases hospital readmission and mortality rates in male patients with heart failure. // Arq Bras Cardiol. 2015;105(3):256-264.

10. Wang W., Jiang T., Li C. et al. Will testosterone replacement therapy become a new treatment of chronic heart failure? A review based on 8 clinical trials. // J Thorac Dis. 2016 May;8(5):269-77.

11. Wang X.F., Qu X.Q., Zhang T.T. et al. Testosterone suppresses ventricular remodeling and improves left ventricular function in rats following myocardial infarction. // Exp Ther Med. 2015 Apr;9(4):1283-1291.

12. Енина Т.Н. , Кузнецов В.А., Солдатова А.М. и др. Биохимические аспекты гендерных различий ответа на сердечную ресинхронизирующую терапию. // Сердце. 2017; 2:103-109.

13. Zusterzeel R., Spatz E.S., Curtis J. P. et al. Cardiac Re-synchronization Therapy in Women Versus Men. Observational Comparative Effectiveness Study From the National Cardiovascular Data Registry. // Circ Cardiovasc Qual Outcomes. 2015;8:4-11.

14. Cheng Y-J., Zhang J., Li W-J.et al. More favorable response to Cardiac resynchronization therapy in women than in men. // Circ Arrhythm Electrophysiol.2014;7:807-815.

15. Biton Y., Zareba W., Goldenberg I. et al. Sex differences in Long-Term Outcomes With Cardiac Resynchronization Therapy in Mild Heart Failure Patients With Left Bundle Branch Block. // J Am Heart Assoc. 2015;4:1-7.

16. Кузнецов В.А., Колунин Г.В., Харац В.Е. и др. «Регистр проведенных операций сердечной ресинхронизирующей терапии». Свидетельство о государственной регистрации базы данных № 2010620077 от 1 февраля 2010 г.

17. Zhang Y.-Z., Xing X.-W., He B. et al. Effects of Testosterone on Cytokines and Left Ventricular Remodeling Following Heart Failure. // Cell Physiol Biochem 2007;20:847-852.

18. Iellamo F., Volterrani M., Caminiti G. et al. Testosterone Therapy in Women With Chronic Heart Failure. // J Am Col Card. 2010; 56(16): 1310-1316.

19. Khazai B., Golden S.H., Colangelo L.A. et al. Association of endogenous testosterone with subclinical atherosclerosis in men: the multi-ethnic study of atherosclerosis. // Clinical Enocrinology.2016;84(5):700-707.

20. Abd A.M., Ellenberg S.S., Swerdloff R. et al. The Cardiovascular Trial of the Testosterone Trials: rationale, design, and baseline data of a clinical trial using computed tomographic imaging to assess the regression of coronary atherosclerosis. // Coronary artery disease. Mar 2016;27(2):95-103.

21. Zheng R., Cao L., Cao W. et al. Risk Factors for Hypogonadism in Male Patients with Type 2 Diabetes. // Journal of Diabetes Research. 2016;2016:5162167.

22. Oikonomou E., Zografos T., Papamikroulis G.A. et al. Biomarkers in atrial fibrillation and heart failure. // Curr Med Chem. 2017 Aug 29. PMID: 28875838.

23. Pathak R., Sen J., Mehta A. et al. Biomarkers and risk of atrial fibrillation: a systematic review and meta-analysis. // Heart, Lung and Circulation. 2015;24(3):185.

24. Norata G.D., Tibolla G., Seccomandi P.M. Dihydrotestosterone decreases tumor necrosis factor-alpha and lipopolysacharode-induced inflammatory response in human endotelial cells. // J Clin Endocrinol Metab. 2006 Feb;91(2):546-54.

25. Corcoran M.P., Meydani M., Lichtenstein A.H. et al. Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in macrophages from older men and postmenopausal women. // J of Endocrino-logy.2010;206:217-224

26. Ishikava T., Harada T., Kubota T. et al. Testosterone inhibits matrix metalloproteinase-1 production in human endometrial stroma cells in vitro. // Reproad 2007;133:6:1233-1239.

27. Oskui P.M., French W.J., Herring M.J. et al. Testosterone and the cardiovascular system: a comprehensive review of the clinical literature. J Am Heart Assoc. 2013 Nov 15;2(6):e000272.

28. Malkin C.J., Pugh P.J., Jones R.D. et al. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. // Journal of Clinical Endocrinology and Metabolism. 2004;89(7):3313-3318.

29. Rabinovich G.A. An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer. // Scand J Immunol. 2007;66:143- 158.

30. Liu F.T. Regulatory roles of galectins in the immune response. // Int Arch Allerg Immunol 2005;136:385-400.

31. Ukkola O., Huttunen T., Puurunen V-P. Total testosterone levels, metabolic parameters, cardiac remodeling and exercise capacity in coronary artery disease patients with different stage of glucose tolerance. // Annals of medi-cine.2013;45(3):206-212.