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ROLE OF CONNEXINS AND SODIUM CHANNEL NAV1.5 CODED BY THE SCN5A GENE IN ALTERATIONS OF THE ELECTRIC IMPULSE CONDUCTION IN THE MYOCARDIUM

Abstract

The role of intercellular gap contacts in the pathogeny of cardiac arrhythmias are considered, examples of mutations associated with atrial fibrillation and atrial asystole are given.

About the Authors

I. V. Pronicheva
Научный центр сердечно-сосудистой хирургии им. А.Н.Бакулева РАМН, Москва
Russian Federation


A. Sh. Revishvili
Научный центр сердечно-сосудистой хирургии им. А.Н.Бакулева РАМН, Москва
Russian Federation


References

1. Заклязьминская Е.В. Генетические основы нарушений сердечного ритма, М., 2007.

2. Antzelevitch C., Brugada P., Brugada J., Brugada R. Brugada Syndrome: from cell to bedside // Curr. Probl. Cardiol. - 2005 - 30 (1) - P. 9-54.

3. Antzelevitch C., Brugada P., Brugada J. et al. Brugada Syndrome. A decade of progress // Circulation Research. - 2002 - Vol. 91. - P. 1114.

4. Chien K.R. Molecular basis of cardiovascular disease. A Companion to Brawnwald’s HEART DISEASE. - 2nd Ed. SAUNDERS, USA, 2004, P. 713.

5. Coppen S., Dupont E., Rothery S. et al. Connexin 45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart // Circulation Research. - 1998. - Vol. 82. - P. 232-243.

6. Groenewegen W. A., Firouzi M., Bezzina C.R. et al. A cardiac sodium channel mutation cosegregates wth a rare connexin40 genotype in familial atrial standstill circulation research // Circ Res. - 2006. 10/24 - Vol. 92. - P. 14-22.

7. Khajavi M., Inoue K., Lupski J.R. Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease // Human Genetics advance online publication, 7 June 2006; doi:10.1038/sj.ejhg.5201649.

8. Makita Naomasa, Sasaki Koji, Groenewegen W. A. et al. Congenital atrial standstill associated with coinheritance of a novel SCN5A mutation and connexin 40 polymorphisms // Heart Rhythm. - 2005. - Vol. 2. - P. 10.

9. Meregalli G.G., Wilde A.M., Tan H.L. Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more? // Cardiovasc. Res. - 2003 - Vol. 57. - P. 367-378.

10. Mohler P.J., Bennett V. Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targeting // Curr. Opin. Cardiol. - 2005 - Vol. 20. - P.189-193.

11. Mohler PJ., Rivolta I., Napolitano C. et al. Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes //Proc. Natl. Acad. Sci. USA. - 2008 -Vol. 101. - P.17533-17538.

12. Nguyen-Tran V.T.D., Kubalak S.W., Minamisawa S. et al. A noval genetic pathway for sudden cardiac death nia defects in the transition between ventricular and conduction system cell lineages // Cell. - 2000. - Vol. 102. - P. 671-682.

13. Plum A., Hallas G., Magin T. et al. Unique and shared functions of different connexins in mice // Curr.Biol. -2000. - Vol. 10. - P.1083-1091.

14. Takehara N., Makita N., Kawabe J. et al. A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill // Journal of Internal Medicine - 2004. Vol. 255 - P. 137-142.

15. Van der Welden. Gap junctional remodeling in relation to stabilization of atrial fibrillation in the goat // Cardiovasc. Res. - 2000. - Vol. 46 - P. 476-486.

16. White T.W. and Bruzzone R. Gap junctions: fates worse than death // Curr.Biol. - 2000 - Vol.10. № 18. - P.685-688.

17. White T.W., Paul1 D.L. Genetic diseases and gene knockouts reveal diverse connexin functions // Annu. Rev. Physiol. 1999. 61:283-310.


Review

For citations:


Pronicheva I.V., Revishvili A.Sh. ROLE OF CONNEXINS AND SODIUM CHANNEL NAV1.5 CODED BY THE SCN5A GENE IN ALTERATIONS OF THE ELECTRIC IMPULSE CONDUCTION IN THE MYOCARDIUM. Journal of Arrhythmology. 2012;67(67):59-62. (In Russ.)

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ISSN 1561-8641 (Print)
ISSN 2658-7327 (Online)